“SIGLEC 10 is an immune checkpoint that inhibits the activation of both innate and adaptive immune cells. In cancer, this can lead to reduced anti-tumor immunity within the tumor microenvironment (“TME”), creating a protected setting for cancer cells to thrive,” said Yang Liu, PhD, Co-Founder, CEO and CSO of OncoC4. “ONC-841 is designed to block this immune checkpoint to rejuvenate immune cell activity for tumor destruction within the TME. We are excited to begin clinical development of ONC-841 in advanced solid tumors.”
SIGLEC 10 has an authentic immunoreceptor tyrosine-based inhibitory motif, which is distinct from some other siglecs such as SIGLEC 15. ONC-841 is a humanized antagonist anti-SIGLEC 10 monoclonal antibody and, to our knowledge, is the first SIGLEC 10 antagonist to enter clinical development.
OncoC4 discovered SIGLEC 10 negatively regulates antibody-dependent cell mediated cytotoxicity (ADCC) in addition to other known functions. ONC-841 was selected and developed based on the ability to enhance antibody-dependent CD16a signaling, a surrogate for ADCC and function of natural killer (NK) cells and macrophages, key innate immune cells involved in tumor killing. Preclinical studies supporting the IND application demonstrated ONC-841 increased the phagocytosis of cancer cells and improved the function of tumor-infiltrating T cells. Additional in vivo syngeneic and xenograft tumor models showed enhanced immune rejection of tumor cells following treatment with ONC-841. Preliminary Phase 1 data on safety, pharmacokinetics, and clinical activity of ONC-841 monotherapy are expected in the second half of 2025.
About OncoC4
Based in Rockville, Maryland, OncoC4 is a privately held, late clinical-stage biopharmaceutical company that is actively engaged in the discovery and development of novel biologics for the potential treatment of cancer. Its most advanced program is BNT316/ONC392 (gotistobart), a Phase 3, next generation anti-CTLA-4 antibody that is designed to allow CTLA-4 to recycle and maintain its protective function against autoimmune diseases while enhancing anti-tumor activity at the same time. In addition, OncoC4 has two first-in-class clinical stage SIGLEC programs, including AI071, a Phase 2 ready SIGLEC agonist designed for difficult to treat immune related adverse events, and ONC-841, a Phase 1 ready SIGLEC 10 antagonist for the treatment of solid tumors. OncoC4’s portfolio also includes preclinical programs targeting the CD24 cancer immune evasion pathway.
More information: www.oncoc4.com.
CONTACTS
OncoC4
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LifeSci Advisors
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LifeSci Advisors
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